- Agriculture Development & Farmers’ Welfare Department
- Backward Communities Development Department
- Coastal Shipping & Inland Navigation Department
- Consumer Affairs Department
- Co-operation Department
- Election Department
- Environment Department
- Finance Department
- Fisheries Department
- Food and Civil Supplies Department
- Forest and Wild Life Department
- General Administration Department
- General Education Department
- Health & Family Welfare Department
- Higher Education Department
- Housing Department
- Information and Public Relations Department
- Industries and Commerce Department
- Electronics & Information Technology Department
- Labour & Skills Department
- Law Department
- Local Self-Government Department
- Non-Resident Keralites Affairs Department
- Planning and Economic Affairs Department
- Public Works Department
- Revenue Department
- Scheduled Tribe Development Department
- Scheduled Castes Development Department
- Science, Technology and Environment Department
- Social Justice Department
- Directorate of Sports and Youth Affairs Department
- Stores Purchase Department
- Taxes Department
- Tourism Department
- Transport Department
- Vigilance Department
- Water Resources Department